Other names: ARB, Arbidol, Umifenovir hydrochloride
Molecular Weight: 513.87544
Appearance: White or off-white crystalline powder
Residue on ignition: ≤0.2％
Description: Arbidol HCl powder cas 131707-23-8 (Umifenovir) is a broad-spectrum antiviral compound that blocks viral fusion, used in treatment of influenza and other respiratory viral infections.
Application: Arbidol HCl powder cas 131707-23-8 inhibits the cell entry of HCV pseudoparticles of genotypes 1a, 1b, and 2a in a dose-dependent fashion.
Arbidol HCl powder cas 131707-23-8 also displays a dose-dependent inhibition of HCV membrane fusion, as assayed by using HCV pseudoparticles (HCVpp) and fluorescent liposomes.
Arbidol HCl powder cas 131707-23-8 is found to present potent inhibitory activity against enveloped and non-enveloped RNA viruses, including FLU-A, RSV, HRV 14 and CVB3 when added before, during, or after viral infection, with IC50 ranging from 2.7 to 13.8 mg/mL.
Arbidol HCl powder cas 131707-23-8 shows selective antiviral activity against AdV-7, a DNA virus, only when added after infection (therapeutic index (TI) = 5.5).
Arbidol HCl powder cas 131707-23-8 induces changes to viral mRNA synthesis of the PB2, PA, NP, NA, and NS genes in MDCK cultures infected with influenza A/PR/8/34.
Arbidol hydrochloride (ARB) is a small monocular compound used as a broad-spectrum inhibitor of influenza A and B virus, parainfluenza virus, respiratory syncytial virus, adenovirus, coxsackievirus and hepatitis C virus infection. It is less likely to induce drug resistance than other compounds, such as adamantine and oseltamivir. However, its mechanism is complicated: earlier reports indicated that ARB could inhibit the membrane fusion of enveloped viruses in vitro and strengthen the interactions between virus glycoprotein and the membrane of host during the endocytosis. However, this scenario cannot explain the antiviral activity of ARB on non-enveloped viruses that directly release genomes into the cytosol without a membrane fusion process14. Moreover, a recent study has found that ARB exhibited only 6% to 8% inhibition of IFV viral fusion from measurements of hemolysis analysis in vitro. It seems that the antiviral efficacy of ARB does not completely depend on the anti-fusion activity.
Other chemical names: Arbidol hydrochloride hydrate, 6-Bromo-4-[(dimethylamino)methyl]-5-hydroxy-1-methyl-2-[(phenylthio)methyl]-,1H-indole-3-carboxylic Acid Ethyl Ester Hydrochloride
Certificate of analysis
|Items of analysis||Standard||Result of analysis|
|Description||White or creamy or siskin-green crystalline powder||Conforms|
|Solubility||Slightly soluble in chloroform and 96% ethyl alcohol, practically insoluble in water||Conforms|
|Should show positive reaction of chlorides and bromides||Conforms|
|Related substance||Single impurity ≤0.5％
Total impurities ≤1.0％
|Residue on ignition||≤0.1％||Conforms|
|Residual solvents||Acetone NMT 0.4%||0.02%|
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